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neuron, or the M-cell, is part of the vertebrate central nervous system.
In the past,
identifying the M-cell has led to discoveries in fields such as the molecular
biology of neurons, behavior, and development.
reticulospinal neuron appears at approximately 7.5 hours post fertilization.
and amphibia have a pair of Mauthner cells, one on each side of the brainstem.
The soma of
each cell is about 100 μm in diameter. There are two major dendrites,
approximately 500 μm in length. The axon extends along the spinal chord.
cells act as sensory integration centers. They are modulated by a group of
The M-cells inhibit these neurons?investigations of this process have led to a
greater understanding of inhibitory synaptic transmission in the vertebrate
central nervous system.
Reciprocal inhibition between the interneurons and the Mauthner neurons ensure
that only one of the M-cells responds to sensory stimuli.
When one M cell is activated, the other is inhibited.
neuron plays a role in the first stage of the C-start
It triggers a predator avoidance response
It is the first neuron to respond to an abrupt sensory input and determines the
initial direction of movement
Zebrafish respond to tail stimulation with C-start
M-cell is not important in the recovery of the C-start response, it
regenerates after a spinal chord injury at the spinomedullary level.**
studies of M-cells in fish have revealed that there is a large structural
difference among fish species.
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